APL-501: Anti Programmed Death-1
APL-501 is a novel IgG4 humanized monoclonal antibody against the Programmed Death-1 (PD-1) membrane receptor on immune cells. It has a comparable efficacy profile in in vitro and in vivo studies to the marketed anti-PD-1 antibodies, nivolumab and pembrolizumab, and has a favorable profile with very low antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) activity.
PD‑1 protein is expressed on immune cells called T cells normally acting as a type of "off switch" that helps keep the T cells from attacking other cells in the body (e.g. healthy cells). PD‑L1 protein is expressed on some normal cells and on cancer cells. PD-1 binds to PD‑L1 and this interaction signals T cells to leave the other cell alone and not attack it. This protects normal, healthy cells from immune attack. But, some cancer cells hijack PD‑L1 expression so the PD-1 expressing T cell adopts a “don’t attack” state which helps the cancer cells hide from the immune system and subsequently grow. Therapies that target PD-1 stop it from interacting with PD-L1. Similarly, therapies that target PD-L1 prevent PD-1 from interacting with it. This allows the T cell to attack cancer cells in the body and prevent them from hiding.
Apollomics retains worldwide rights to APL-501 outside of China.
APL-501 is currently being evaluated in several ongoing clinical trials. For additional information, please click on the trial links below.